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1

Morphology Control in Water of Polyion Complex Nanoarchitectures of Double-Hydrophilic Charged Block Copolymers through Composition Tuning and Thermal Treatment

Wibowo, Arie, Osada, Kensuke, Matsuda, Hiroyuki, Anraku, Yasutaka, Hirose, Haruko, Kishimura, Akihiro, Kataoka, Kazunori

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.66 MB

english, 2014

2

Therapeutic Vesicular Nanoreactors with Tumor-Specific Activation and Self-Destruction for Synergistic Tumor Ablation

Li, Junjie, Dirisala, Anjaneyulu, Ge, Zhishen, Wang, Yuheng, Yin, Wei, Ke, Wendong, Toh, Kazuko, Xie, Jinbing, Matsumoto, Yu, Anraku, Yasutaka, Osada, Kensuke, Kataoka, Kazunori

Journal:

Angewandte Chemie International Edition

Année:

2017

Langue:

english

Fichier:

PDF, 8.12 MB

english, 2017

3

Thermotropic Liquid Crystals of Main-Chain Polyesters having a Mesogenic 4,4′-Biphenyldicarboxylate Unit, 14

Kensuke Osada, Masao Koike, Hirotaka Tagawa, Masatoshi Tokita, Junji Watanabe

Journal:

Macromolecular Chemistry and Physics

Année:

2004

Langue:

english

Fichier:

PDF, 143 KB

english, 2004

4

Polyplex nanomicelle promotes hydrodynamic gene introduction to skeletal muscle

Keiji Itaka, Kensuke Osada, Katsue Morii, Pilhan Kim, Seok-Hyun Yun, Kazunori Kataoka

Journal:

Journal of Controlled Release

Année:

2010

Langue:

english

Fichier:

PDF, 2.15 MB

english, 2010

5

Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination

Michiaki Kumagai, Shinya Shimoda, Rie Wakabayashi, Yumi Kunisawa, Takehiko Ishii, Kensuke Osada, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka, Kenji Nakano

Journal:

Journal of Controlled Release

Année:

2012

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2012

6

Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles

Frederico Pittella, Kanjiro Miyata, Yoshinori Maeda, Tomoya Suma, Sumiyo Watanabe, Qixian Chen, R. James Christie, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka

Journal:

Journal of Controlled Release

Année:

2012

Langue:

english

Fichier:

PDF, 478 KB

english, 2012

7

Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency against Pancreatic Tumor

Mochida, Yuki, Cabral, Horacio, Miura, Yutaka, Albertini, Francesco, Fukushima, Shigeto, Osada, Kensuke, Nishiyama, Nobuhiro, Kataoka, Kazunori

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 6.83 MB

english, 2014

8

Block Copolymer Micelles in Nanomedicine Applications

Cabral, Horacio, Miyata, Kanjiro, Osada, Kensuke, Kataoka, Kazunori

Journal:

Chemical Reviews

Année:

2018

Langue:

english

Fichier:

PDF, 9.15 MB

english, 2018

9

A Synthetic Block Copolymer Regulates S1 Nuclease Fragmentation of Supercoiled Plasmid DNA

Kensuke Osada, Yuichi Yamasaki, Satoshi Katayose, Kazunori Kataoka

Journal:

Angewandte Chemie

Année:

2005

Langue:

english

Fichier:

PDF, 428 KB

english, 2005

10

Encapsulation of Myoglobin in PEGylated Polyion Complex Vesicles Made from a Pair of Oppositely Charged Block Ionomers: A Physiologically Available Oxygen Carrier

Akihiro Kishimura, Aya Koide, Kensuke Osada, Yuichi Yamasaki, Kazunori Kataoka

Journal:

Angewandte Chemie

Année:

2007

Langue:

english

Fichier:

PDF, 288 KB

english, 2007

11

Charge-Conversional Polyionic Complex Micelles—Efficient Nanocarriers for Protein Delivery into Cytoplasm

Yan Lee, Takehiko Ishii, Horacio Cabral, Hyun Jin Kim, Ji-Hun Seo, Nobuhiro Nishiyama, Hiroki Oshima, Kensuke Osada, Kazunori Kataoka

Journal:

Angewandte Chemie

Année:

2009

Langue:

english

Fichier:

PDF, 688 KB

english, 2009

12

Innentitelbild: Charge-Conversional Polyionic Complex Micelles—Efficient Nanocarriers for Protein Delivery into Cytoplasm (Angew. Chem. 29/2009)

Yan Lee, Takehiko Ishii, Horacio Cabral, Hyun Jin Kim, Ji-Hun Seo, Nobuhiro Nishiyama, Hiroki Oshima, Kensuke Osada, Kazunori Kataoka

Journal:

Angewandte Chemie

Année:

2009

Fichier:

PDF, 474 KB

2009

13

A Synthetic Block Copolymer Regulates S1 Nuclease Fragmentation of Supercoiled Plasmid DNA

Kensuke Osada, Yuichi Yamasaki, Satoshi Katayose, Kazunori Kataoka

Journal:

Angewandte Chemie International Edition

Année:

2005

Langue:

english

Fichier:

PDF, 428 KB

english, 2005

14

Encapsulation of Myoglobin in PEGylated Polyion Complex Vesicles Made from a Pair of Oppositely Charged Block Ionomers: A Physiologically Available Oxygen Carrier

Akihiro Kishimura, Aya Koide, Kensuke Osada, Yuichi Yamasaki, Kazunori Kataoka

Journal:

Angewandte Chemie International Edition

Année:

2007

Langue:

english

Fichier:

PDF, 288 KB

english, 2007

15

Charge-Conversional Polyionic Complex Micelles—Efficient Nanocarriers for Protein Delivery into Cytoplasm

Yan Lee, Takehiko Ishii, Horacio Cabral, Hyun Jin Kim, Ji-Hun Seo, Nobuhiro Nishiyama, Hiroki Oshima, Kensuke Osada, Kazunori Kataoka

Journal:

Angewandte Chemie International Edition

Année:

2009

Langue:

english

Fichier:

PDF, 688 KB

english, 2009

16

Inside Cover: Charge-Conversional Polyionic Complex Micelles—Efficient Nanocarriers for Protein Delivery into Cytoplasm (Angew. Chem. Int. Ed. 29/2009)

Yan Lee, Takehiko Ishii, Horacio Cabral, Hyun Jin Kim, Ji-Hun Seo, Nobuhiro Nishiyama, Hiroki Oshima, Kensuke Osada, Kazunori Kataoka

Journal:

Angewandte Chemie International Edition

Année:

2009

Langue:

english

Fichier:

PDF, 480 KB

english, 2009

17

Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide–Gold Core–Shell Nanoparticles with Prolonged Blood Circulation Properties

Michiaki Kumagai, Tridib Kumar Sarma, Horacio Cabral, Sachiko Kaida, Masaki Sekino, Nicholas Herlambang, Kensuke Osada, Mitsunobu R. Kano, Nobuhiro Nishiyama, Kazunori Kataoka

Journal:

Macromolecular Rapid Communications

Année:

2010

Langue:

english

Fichier:

PDF, 580 KB

english, 2010

18

Macromol. Rapid Commun. 17/2010

Michiaki Kumagai, Tridib Kumar Sarma, Horacio Cabral, Sachiko Kaida, Masaki Sekino, Nicholas Herlambang, Kensuke Osada, Mitsunobu R. Kano, Nobuhiro Nishiyama, Kazunori Kataoka

Journal:

Macromolecular Rapid Communications

Année:

2010

Fichier:

PDF, 379 KB

2010

19

Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery

Makoto Oba, Kanjiro Miyata, Kensuke Osada, R. James Christie, Mai Sanjoh, Weidong Li, Shigeto Fukushima, Takehiko Ishii, Mitsunobu R. Kano, Nobuhiro Nishiyama, Hiroyuki Koyama, Kazunori Kataoka

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.54 MB

english, 2011

20

Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity

Frederico Pittella, Mingzhen Zhang, Yan Lee, Hyun J. Kim, Theofilus Tockary, Kensuke Osada, Takehiko Ishii, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2011

21

Targeted Polymeric Micelles for siRNA Treatment of Experimental Cancer by Intravenous Injection

Christie, R. James, Matsumoto, Yu, Miyata, Kanjiro, Nomoto, Takahiro, Fukushima, Shigeto, Osada, Kensuke, Halnaut, Julien, Pittella, Frederico, Kim, Hyun Jin, Nishiyama, Nobuhiro, Kataoka, Kazunori

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 963 KB

english, 2012

22

Enhanced gene expression promoted by the quantized folding of pDNA within polyplex micelles

Kensuke Osada, Tomonori Shiotani, Theofilus A. Tockary, Daigo Kobayashi, Hiroki Oshima, Sorato Ikeda, Ronald J. Christie, Keiji Itaka, Kazunori Kataoka

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 693 KB

english, 2012

23

Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors

Qixian Chen, Kensuke Osada, Takehiko Ishii, Makoto Oba, Satoshi Uchida, Theofilus A. Tockary, Taisuke Endo, Zhishen Ge, Hiroaki Kinoh, Mitsunobu R. Kano, Keiji Itaka, Kazunori Kataoka

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2012

24

Combination of chondroitin sulfate and polyplex micelles from Poly(ethylene glycol)-poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity

Satoshi Uchida, Keiji Itaka, Qixian Chen, Kensuke Osada, Kanjiro Miyata, Takehiko Ishii, Mariko Harada-Shiba, Kazunori Kataoka

Journal:

Journal of Controlled Release

Année:

2011

Langue:

english

Fichier:

PDF, 755 KB

english, 2011

25

PEGylated Polyplex With Optimized PEG Shielding Enhances Gene Introduction in Lungs by Minimizing Inflammatory Responses

Uchida, Satoshi, Itaka, Keiji, Chen, Qixian, Osada, Kensuke, Ishii, Takehiko, Shibata, Masa-Aki, Harada-Shiba, Mariko, Kataoka, Kazunori

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 681 KB

english, 2012

26

Ultrasound-Mediated Gene Transfection In vitro : Enhanced Efficiency by Complexation of Plasmid DNA

Zhang, Yiwei, Tachibana, Rie, Okamoto, Akio, Azuma, Takashi, Sasaki, Akira, Yoshinaka, Kiyoshi, Osada, Kensuke, Kataoka, Kazunori, Takagi, Shu, Matsumoto, Yoichiro

Journal:

Japanese Journal of Applied Physics

Année:

2012

Langue:

english

Fichier:

PDF, 428 KB

english, 2012

27

Elongation Behavior of a Main-Chain Smectic Liquid Crystalline Elastomer

Ishige, Ryohei, Osada, Kensuke, Tagawa, Hirotaka, Niwano, Hiroko, Tokita, Masatoshi, Watanabe, Junji

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 529 KB

english, 2008

28

Geodetic constraints on afterslip characteristics following the March 9, 2011, Sanriku-oki earthquake, Japan

Ohta, Yusaku, Hino, Ryota, Inazu, Daisuke, Ohzono, Mako, Ito, Yoshihiro, Mishina, Masaaki, Iinuma, Takeshi, Nakajima, Junichi, Osada, Yukihito, Suzuki, Kensuke, Fujimoto, Hiromi, Tachibana, Kenji, Dem

Journal:

Geophysical Research Letters

Année:

2012

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2012

29

Effect of Polymer Structure on Micelles Formed between siRNA and Cationic Block Copolymer Comprising Thiols and Amidines

Christie, R. James, Miyata, Kanjiro, Matsumoto, Yu, Nomoto, Takahiro, Menasco, Daniel, Lai, Tzai Chung, Pennisi, Matthew, Osada, Kensuke, Fukushima, Shigeto, Nishiyama, Nobuhiro, Yamasaki, Yuichi, Kat

Journal:

Biomacromolecules

Année:

2011

Langue:

english

Fichier:

PDF, 4.39 MB

english, 2011

30

Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers

Tockary, Theofilus A., Osada, Kensuke, Chen, Qixian, Machitani, Kaori, Dirisala, Anjaneyulu, Uchida, Satoshi, Nomoto, Takahiro, Toh, Kazuko, Matsumoto, Yu, Itaka, Keiji, Nitta, Koji, Nagayama, Kuniaki

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 2.57 MB

english, 2013

31

Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer–Metal Complexation

Osada, Kensuke, Cabral, Horacio, Mochida, Yuki, Lee, Sangeun, Nagata, Kazuya, Matsuura, Tetsuya, Yamamoto, Megumi, Anraku, Yasutaka, Kishimura, Akihiro, Nishiyama, Nobuhiro, Kataoka, Kazunori

Journal:

Journal of the American Chemical Society

Année:

2012

Langue:

english

Fichier:

PDF, 1.70 MB

english, 2012

32

Quantized Folding of Plasmid DNA Condensed with Block Catiomer into Characteristic Rod Structures Promoting Transgene Efficacy

Osada, Kensuke, Oshima, Hiroki, Kobayashi, Daigo, Doi, Motoyoshi, Enoki, Manabu, Yamasaki, Yuichi, Kataoka, Kazunori

Journal:

Journal of the American Chemical Society

Année:

2010

Langue:

english

Fichier:

PDF, 2.82 MB

english, 2010

33

Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors

Ge, Zhishen, Chen, Qixian, Osada, Kensuke, Liu, Xueying, Tockary, Theofilus A., Uchida, Satoshi, Dirisala, Anjaneyulu, Ishii, Takehiko, Nomoto, Takahiro, Toh, Kazuko, Matsumoto, Yu, Oba, Makoto, Kano,

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 2.09 MB

english, 2014

34

Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors

Dirisala, Anjaneyulu, Osada, Kensuke, Chen, Qixian, Tockary, Theofilus A., Machitani, Kaori, Osawa, Shigehito, Liu, Xueying, Ishii, Takehiko, Miyata, Kanjiro, Oba, Makoto, Uchida, Satoshi, Itaka, Keij

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.86 MB

english, 2014

35

Intrasulcal electrocorticography in macaque monkeys

Kawasaki, Keisuke, Matsuo, Takeshi, Osada, Takahiro, Sawahata, Hirohito, Suzuki, Takafumi, Shibata, Masahiro, Miyakawa, Naohisa, Nakahara, Kiyoshi, Sato, Noboru, Kawai, Kensuke, Saito, Nobuhito, Haseg

Journal:

Neuroscience Research

Année:

2011

Langue:

english

Fichier:

PDF, 124 KB

english, 2011

36

Episodic slow slip events in the Japan subduction zone before the 2011 Tohoku-Oki earthquake

Ito, Yoshihiro, Hino, Ryota, Kido, Motoyuki, Fujimoto, Hiromi, Osada, Yukihito, Inazu, Daisuke, Ohta, Yusaku, Iinuma, Takeshi, Ohzono, Mako, Miura, Satoshi, Mishina, Masaaki, Suzuki, Kensuke, Tsuji, T

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 2.71 MB

english, 2013

37

Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer

Nomoto, Takahiro, Fukushima, Shigeto, Kumagai, Michiaki, Machitani, Kaori, Arnida,, Matsumoto, Yu, Oba, Makoto, Miyata, Kanjiro, Osada, Kensuke, Nishiyama, Nobuhiro, Kataoka, Kazunori

Journal:

Nature Communications

Année:

2014

Langue:

english

Fichier:

PDF, 2.79 MB

english, 2014

38

MORPHOLOGICAL INVESTIGATIONS OF ACHNANTHES JAVANICA GRUNOW AND A. SUBCONSTRICTA (MEISTER) COMB. NOV.

Toyoda, Kensuke, Nagumo, Tamotsu, Osada, Keigo, Tanaka, Jiro

Journal:

Diatom Research

Année:

2003

Langue:

english

Fichier:

PDF, 2.91 MB

english, 2003

39

Parallel and Perpendicular Orientations Observed in Shear Aligned S CA Liquid Crystal of Main-Chain Polyester

Tokita, Masatoshi, Tokunaga, Kengo, Funaoka, Shin-ichiro, Osada, Kensuke, Watanabe, Junji

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 116 KB

english, 2004

40

Semipermeable Polymer Vesicle (PICsome) Self-Assembled in Aqueous Medium from a Pair of Oppositely Charged Block Copolymers: Physiologically Stable Micro-/Nanocontainers of Water-Soluble Macromolecules

Koide, Aya, Kishimura, Akihiro, Osada, Kensuke, Jang, Woo-Dong, Yamasaki, Yuichi, Kataoka, Kazunori

Journal:

Journal of the American Chemical Society

Année:

2006

Langue:

english

Fichier:

PDF, 870 KB

english, 2006

41

Phase Behavior of Crystal Polymorphs of Thermotropic Poly(hexamethylene 4,4‘-biphenyldicarboxylate) under Hydrostatic Pressure

Maeda, Yoji, Osada, Kensuke, Watanabe, Junji

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 182 KB

english, 2000

42

Chain-Folded Lamellar Structure in the Smectic H Phase of a Main-Chain Polyester

Tokita, Masatoshi, Osada, Kensuke, Yamada, Masayuki, Watanabe, Junji

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 95 KB

english, 1998

43

Thermotropic Liquid Crystals of Main-Chain Polyesters Having a Mesogenic 4,4‘-Biphenyldicarboxylate Unit. 13. Characteristic Deformation of Smectic Layer Structure Induced by Elongation of Uniaxially Oriented Fiber Composed of Smectic CA Glass

Osada, Kensuke, Niwano, Hiroko, Tokita, Masatoshi, Kawauchi, Susumu, Watanabe, Junji

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 160 KB

english, 2000

44

Two Distinct Types of Orientation Process Observed in Uniaxially Elongated Smectic LC Melt

Osada, Kensuke, Koike, Masao, Tagawa, Hirotaka, Hunaoka, Shin-ichiro, Tokita, Masatoshi, Watanabe, Junji

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 226 KB

english, 2005

45

NanoPARCEL: a method for controlling cellular behavior with external light

Murayama, Shuhei, Su, Baowei, Okabe, Kohki, Kishimura, Akihiro, Osada, Kensuke, Miura, Masayuki, Funatsu, Takashi, Kataoka, Kazunori, Kato, Masaru

Journal:

Chemical Communications

Année:

2012

Langue:

english

Fichier:

PDF, 1.51 MB

english, 2012

46

Preliminary communication Thermotropic liquid crystals in main chain polyesters having a mesogenic 4,4-biphenyldicarboxylate unit. 9. Chain folding in solid polyesters crystallized from smectic A

TOKITA, MASATOSHI, OSADA, KENSUKE, WATANABE, JUNJI

Journal:

Liquid Crystals

Année:

1997

Langue:

english

Fichier:

PDF, 161 KB

english, 1997

47

Preliminary communication Thermotropic liquid crystals of polyesters having a mesogenic p,p' -bibenzoate unit X. Distinct orientation of molecules in a thin SmCA film stretched from isotropic melt, providing evidence for the biaxiallity of the SmCA p

TOKITA, MASATOSHI, OSADA, KENSUKE, WATANABE, JUNJI

Journal:

Liquid Crystals

Année:

1998

Langue:

english

Fichier:

PDF, 273 KB

english, 1998

48

Development of functional polyplex micelles for systemic gene therapy

Journal:

Polymer Journal

Année:

2014

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2014

49

Feasibility of a subcutaneously administered block/homo-mixed polyplex micelle as a carrier for DNA vaccination in a mouse tumor model

Cui, Lin, Osada, Kensuke, Imaizumi, Akira, Kataoka, Kazunori, Nakano, Kenji

Journal:

Journal of Controlled Release

Année:

2015

Langue:

english

Fichier:

PDF, 1.24 MB

english, 2015

50

Ternary polyplex micelles with PEG shells and intermediate barrier to complexed DNA cores for efficient systemic gene delivery

Li, Junjie, Chen, Qixian, Zha, Zengshi, Li, Hui, Toh, Kazuko, Dirisala, Anjaneyulu, Matsumoto, Yu, Osada, Kensuke, Kataoka, Kazunori, Ge, Zhishen

Journal:

Journal of Controlled Release

Année:

2015

Langue:

english

Fichier:

PDF, 2.14 MB

english, 2015